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ApherisFold

Run the latest co-folding models, such as OpenFold3 and Boltz-2, securely within your own environment — giving you full control over data, benchmarking, and fine-tuning.

Apply co-folding models to your drug discovery programs while keeping your data fully protected

Benchmark models on your in-house data


Explore outputs via a GUI or integrate them into existing workflows


Securely customize models to your domains of interest (on own or third-party data)

Optimized for enterprise security and scalability requirements

Built for scientists, ApherisFold integrates seamlessly into existing R&D stack — supplementing, not replacing, your internal pipelines. It scales efficiently across multiple GPUs, users, and models, and meets enterprise-grade security and performance requirements.

Documentation

Secure local inference

Deployed ApherisFold locally such that no data leaves your corporate network and internal security policies are met.

In-house model benchmarking

Securely evaluate and compare models on your in-house data using performance guidelines and a benchmarking kit.

Model customization

Securely customize models to your domain of interests, either on your own data or on third-party data via federated data networks.

Visualization and integration

Explore 3D molecular visualization through a scientist-friendly GUI or connect outputs to existing drug discovery workflows programmatically via an API.

Dr. Lukas Pluska

Read Lukas's Co-Folding blog

to find out why co-folding models, such as AlphaFold 3, Boltz‑2, and OpenFold3, show decreased accuracy on novel targets. Learn how to critically assess their applicability domain, and why customizing these models to your own research tasks is essential for achieving meaningful results.

Co-Folding Blog

Securely use the latest co-folding models, like OpenFold3 and Boltz-2, on your proprietary data.

Join the waitlist, and we’ll let you know as soon as it’s live.